For modern thermal applications, open cell porous metals provide interesting opportunities to increase performance. Several types of cellular metalsshow an anisotropic morphology. Thus, using different orientations of the structure can boost or destroy the performance in thermal applications. Examples of such cellular anisotropic structures are lotus-root structures and expanded metal and fiber structures. While lotus-root structures are made by casting and show unidirectional pores, expanded metal structures and fiber structures are made from loose semi-finished products joined by sintering and form a fully open porous structure. Small to large differences, factor 1.5 to factor 25, in heat conductivity and pressure drop can be observed for different orientations. Literature data and own measurements of these properties are presented and discussed. Examples of advantageous applications, where the preferential orientations are exploited in order to gain the full capacity of the structure’s performance, are introduced. This includes a latent heat storage device and a heat exchanger where the preferential orientations are shown as best case example.